Although research with this particular combination strategy is not extensive, there are several studies demonstrating its high degree of efficacy among those with refractory depression.In all studies, the “rocket fuel” proved to be more effective than other antidepressant combinations.These were administered to patients that weren’t able to get benefit from at least 3 previous medication trials.

The reason this combination is referred to as “California rocket fuel” is due to the its higher than average potency and efficacy.

Rockets blast off with extreme speed, and in many cases, people given this particular combination notice a rapid improvement in their depressive symptoms. to treat depression in 1996 and some comparison studies go as far as to suggest that it has the single highest efficacy of any antidepressant on the market.

Whether this is universally the most effective combination of multiple antidepressants is subject to debate.

A study conducted in 2006 compared the efficacy of Remeron in conjunction with either Parnate or Effexor.

In a 2009 double-blind, randomized trial, various antidepressant combination treatments were investigated to determine their efficacies.

Researchers conducted this study due to the fact that only one-third (~33%) of patients taking antidepressants tend to experience improvement in their depressive symptoms from monotherapy.

Also known as: Remeron, Remeron Sol Tab The following information is NOT intended to endorse drugs or recommend therapy.

While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

Generally, this combination is prescribed only when someone is faced with a severe case of major depression that hasn’t responded to at least three prior antidepressant trials.

In some cases, depending on the psychiatrist, all monotherapeutic options will first need to be explored before practicing poly-pharmacology.

Remeron (Mirtazapine): This drug functions as an “Na SSA” antidepressant. Although it has relatively average tolerability, for many people with severe forms of depression, there’s nothing that works better than Remeron.