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RESULTS: 333 consecutive patient responses were collected. RESULTS: Eighty-nine patients are enrolled in the LESSGERD Registry, of whom 39 have available data at baseline and 6 months post-op.
Patients suffered from GERD for an average of 8.6 years and prescribed PPI therapy for an average duration of 6.4 years. All but three (36/39; 92%) patients showed an improvement in their GERD-HRQL score on LESES compared to baseline.
39% of patients reported heartburn at least 2 days per week (20% 4-7 days per week), 30% complained of regurgitation at least 2 days per week (13% 4-7 days per week), and 22% reported symptoms disrupting sleep at least twice per week (6% 4-7 days per week). Hani, Michael Booth, Alex Escalona, Abraham Botha, Justin C. Overall, the median (IQR) composite GERD-HRQL score improved from 22 (18-27) preoperatively to 8.0 (3.5-12.5) at 6-month follow-up (p View Full Article BACKGROUND: Two open-label trials have shown that Electrical stimulation therapy (EST) of the lower esophageal sphincter (LES) (LES-EST) significantly improves esophageal acid exposure and symptoms in GERD patients.
20% of patients were dissatisfied on their current PPI therapy (score of 1 or 2 on a scale of 1-5, 1=very dissatisfied, 5=very satisfied), and 14% were both dissatisfied and had a high likelihood of complaints correlating to pathological p H based on the Gerd Q questionnaire. Following review of these results, 75% of GPs surveyed (n=8) agree that reflux patients with remaining symptoms on PPI is more of a problem than they previously thought. However, the underlying antireflux mechanism(s) of LES-EST remain(s) unclear.
No SAEs related to the device or procedure were reported.
No dysphagia or other GI side effects were reported.
Data from a larger patient experience for this indication is being collected using the international registry trial.
View Full Article BACKGROUND: Randomized controlled trials report about 30% of GERD patients complain of bothersome remaining symptoms (heartburn, regurgitation) despite PPI.
A total of 86% of patients received an upper endoscopy in the past, but only 8% had a prior p H-metry and 2% manometry. CONCLUSION: Inadequate control of symptoms is common in GERD patients prescribed PPI therapy, and is often overlooked in daily practice. AIM: The aim of this study is to evaluate the effect of EST on postprandial reflux mechanisms, especially on transient LES relaxations (TLESRs).
These patients with insufficient symptom control should be methodically identified and considered for further diagnostics and/or treatment modification, for example with a screening questionnaire. METHODS: We studied 10 chronic GERD patients with abnormal acid exposure (p H Gastroenterology, Volume 150, Issue 4, S476.
However, LSG can result in new GERD and may worsen pre-existing GERD.