Burrows modeled for Marks & Spencer's autumn 2010 campaign for their Portfolio range. In 20, Burrows joined the ranks of the Marvel Cinematic Universe on the ABC television show Agents of S. The play then toured, visiting the Theatre National Du Chaillot, Paris, and the Teatro Argentina, Rome.

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Saffron Barker is a singer, You Tuber, and one of Britain’s most prominent social media celebrities.

On her main You Tube channel she has 880K subscribers, while her vlogging channel has more than half a million subscribers.

In December 2016, she was one of the 25 You Tubers who recorded ‘Christmas Without You’, a charity Christmas single benefiting ‘Make-A-Wish Foundation’.

The song was penned by Grammy Award winning songwriters ‘Jackie Boys’.

In 2006, Burrows was the female lead in the New Zealand thriller Perfect Creature. She starred in the Amazon Video show Mozart in the Jungle as Cynthia Taylor, a philandering cellist with the New York Symphony. Burrows is openly bisexual, and has said that she "prefers the company of women." She was previously engaged to actor Alan Cumming in the 1990s, and dated director Mike Figgis for five years until 2002.

That same year, she worked with Chilean director Raoul Ruiz on Klimt, his cinematic version of the life of Gustav Klimt. She played opposite Kevin Spacey in Jonas Pate's Shrink. She has contributed to the Actors Come Clean for Congo video for the Raise Hope for Congo campaign, a campaign of the Enough Project, in support of the conflict mineral issue. In September 2010, she took part in the documentary feature film The People Speak, directed and produced by Colin Firth and Anthony Arnove, televised on the History Channel, linked with The People Speak (Film) – International. Her content mostly involves beauty, fashion, lifestyle, music, Q&As, and challenges which she does with her friends and family.She is quite famous on other social media platforms as well, with 640K and 266K followers on Instagram and Twitter respectively, 35K Facebook likes, and 27.9K You Now fans.Burrows made her film debut in 1993 with a small role in Jim Sheridan's In the Name of the Father.